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Prof. TIAN Changlin


TIAN Changlin



Education Background



Molecular Biophysics


Visit the website of Dr. TIAN Changlin's laboratory 


Biography & Introduction


Education Background

Sep. 1997 - May 2003    Ph.D. in Molecular Biophysics, Institute of Biophysics

                                            Florida State University

Sep. 1995 - Jul. 1997     M.S.  in Molecular Biology, Department of Biological Science and Technology

                                            Shanghai Jiao Tong University
Sep. 1991 - Jul. 1995     B.S.  in Applied Electronic Technology, Department of Information Control
                                            B.S.  in Biochemical Engineering, Department of Biological Science and Technology

                                            Shanghai Jiao Tong University


Professional Activities

Aug. 2009 - Present        Deputy director, High Magnetic Field Laboratory, Chinese Academy of Sciences

Nov. 2006 - Present        Professor, Biochemistry and Molecular Biology, School of Life Science

                                            University of Science and Technology of China,
Mar. 2003 - Feb. 2007     Postdoctoral research associate, Center for Structural Biology, School of Medicine

                                              Vanderbilt University

Jan. 1998 - Mar. 2003     Research assistant, Center for Interdisciplinary of Magnetic Resonance

                                             National High Magnetic Field Laboratory

Awards and Honors

Sep. 2009 - Present         Associate director, Molecular Biophysics Committee, Chinese Biophysics Society
Sep. 2009 - Present         Editor, Board of Sinica Biophysics Acta.
Apr. 2009 - Present         General secretary, Anhui Biochemistry and Molecular Biology Association
Dec. 2008         Young Faculty Career Award, University of Science and Technology of China Alumni Foundation
Dec. 2007         Young Investigator Award, Huo-Ying-Dong Education Foundation
Jan. 2006 - Dec. 2008         Postdoctoral Fellowship Award, American Heart Association (stopped on 03/2006, due to resignation from Vanderbilt University)




Research Interests

Research interests in Dr. TIAN Changlin's lab are focusing on the structure and dynamic studies of membrane proteins, using combinational methods of solution nuclear magnetic resonance (NMR), electronic paramagnetic resonance (EPR), X-ray crystallography, and small angle X-ray scattering (SAXS). Research topics include transporter and channel proteins in Mycobacterium tuberculosis, mouse and human being, human G protein coupled receptors, and other large size membrane associated proteins. Some cutting edge biological technologies, such as unnatural amino acids and their application in structural biology, automatic electrophysiology analysis, receptor pharmacology studies are applied to aid structural anddynamic studies of membrane proteins. 


Current Research Projects 

  1. Structure, Dynamics and Physiology studies of Potassium Channel and its Modulation Protein
  2. Method Development of Magnetic Resonance (NMR, EPR) and combination studies with other biophysical methods


Selected Publications

  1. Shi P, Wang H, Xi Z, Shi C, Xiong Y, Tian C, Site-Specific 19F NMR Chemical Shift and Side Chain Relaxation Analysis of a Membrane Protein Labeled with an Unnatural Amino Acid, Protein Science 20 (2010) 224-228
  2. Xie X, Yang X, Chen L, Tian C, Long J, Shen Y Structural basis for tandem L27 domain-mediated polymerization FASEB J. 24 (2010) 4806-15
  3. Vanoye CG, Welch RC, Tian C, Sanders CR, George AL Jr. KCNQ1/KCNE1 assembly, co-translation not required. Channels 2010 4(2):
  4. Yan X, Zhou H, Zhang J, Shi C, Xie X, Wu Y, Tian C, Shen Y, Long J. Molecular Mechanism of Inward Rectifier Potassium Channel 2.3 Regulation by Tax- Interacting Protein-1 J. Mol. Bio. 2009 392(4):967-976
  5. Van Horn WD, Kim HJ, Ellis CD, Hadziselimovic A, Sulistijo ES, Karra MD, Tian C,S?nnichsen FD, Sanders CR Solution Nuclear Magnetic Resonance Structure of Membrane Integral Diacylglycerol Kinase Science 2009 324(5935): 1726-1729
  6. Kang, C*.,Tian, C*. Sonnichsen, F.D., Smith, J. A., Meiler, J., George, A.L., Vanoye,
    C.G., Kim, H.J., Sanders, C.R. Preparation, Functional Characterization, and NMR Studies of Human KCNE1, Structrue of KCNE1 and Implications for How it Modulates the KCNQ1 Potassium Channel Biochemistry. 2008; 47:7999-8006 (*
    Equal contribution)
  7. Shi, C., Shao, W., Xiong, Y., Tian, C. A Gas Chromatography Method for Quantification of Detergents frequently used in Membrane Protein Structural Studies Anal. Biochem. 2008, 383: 326-328