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Prof. LIN Wenchu
Time:2014-07-18

 

 

LIN Wenchu

Title

Principal Investigator

Education Background

Ph.D.

Major

Biomedical Sciences

       


Visit the website of Dr. LIN Wenchu's Laboratory

 

Biography & Introduction 

Education Background
Ph.D.       in Biomedical Science, 2006, University of Texas M D Anderson Cancer Center
M.S.         in Biochemistry and Molecular Biology, 2001, Chinese Academy of Sciences, Shanghai, China
B.S.         in Microbiology, 1996, Sichuan University, Chengdu, China

Professional Activities
12/2012 – present          Professor, Hefei Institutes of Physics Sciences, CAS, China
04/2012 –12/2012          Research scientist II, Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA, US
05/2007 – 03/2012         Research fellow, Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA, US
12/2006 – 04/2007         Postdoc fellow, University of Texas M D Anderson Cancer Center, Houston, TX, US
05/2002 –12/2006         Graduate research assistant, University of Texas M D Anderson Cancer Center, Houston, TX, US
09/1998 –07/2001         Graduate research assistant, Chinese Academy of Sciences, Shanghai, China

 

Research

 

Research Interests

Cancer genetics and epigenetics, Mouse models of human cancer, Molecular diagnostics of cancer

 

Selected Publications

  1. Hideo Watanabe, Joshua Y. Francis, Michele S. Woo, Banafsheh Etemad, Wenchu Lin, Daniel Fries, …. Tyler Jacks, Matthew Meyerson. Integrated cistromic and expression analysis of amplified NKX2-1 in Lung adenocarcinoma identifies LMO3 as a functional transcriptional target. (2013) Genes & Development. 27(2): 197-210.
  2. Veronica Martínez-Cerde?o V, Jessica M. Lemen, Vanessa Chan, Alice Wey, Wenchu Lin, Sharon R. Dent, Paul S. Knoepfler N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells. (2012) PLoS One. 7(6): e39456.
  3. Wenchu Lin*, Jian Cao*, Jiayun Liu, …… Matthew Meyerson, William G. Kaelin, Jr.,and Qin Yan. Loss of the RBP2 histone demethylase suppresses tumorigenesis in mouse models of Rb1 and Men1 tumor suppressor gene inactivation. (2011) PNAS. 108(33): 13379-86. * Equal contribution.
  4. Peter S. Hammerman,Martin L. Sos,Alex H. Ramos,Chunxiao Xu,Amit Dutt,Wenjun Zhou,Lear E. Brace,Brittany A. Woods,Wenchu Lin,Jianming Zhang,…. Kwok-Kin Wong,Eric B. Haura,Roman K. Thomas,Matthew Meyerson. Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer. (2011) Cancer Discovery. 1(1): 78-89.
  5. Joshua Francis, Wenchu Lin, Orit Rozenblatt-Rosen, Matthew Meyerson. The menin tumor suppressor protein is phosphorylated in response to DNA damage. (2011) PLoS One. 6(1): e16119.
  6. Wenchu Lin, Zhijing Zhang, Geraldine Srajer, Yi Chun Chen, Maosheng Huang, Huy M. Phan, and Sharon Y.R. Dent. Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. (2008) Dev. Dyn. 237(4): 928-940.
  7. Wenchu Lin, Chih-Hsin Chen, Richard R. Behringer, and Sharon Y.R. Dent. Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. (2008) Dev Growth Differ. 50(5): 321-30.
  8. Wenchu Lin*, Geraldine Srajer*, Yvonne A. Evrard, Huy M. Phan, Yas Furuta, and Sharon Y.R. Dent. Developmental potential of Gcn5-/- ES cells in vivo and in vitro. (2007) Dev. Dyn. 236(6): 1547-1557. * Equal contribution.
  9. Ke Zhang, Wenchu Lin, John A. Latham, Gary M. Riefler, Jill M. Schumacher,Clarence Chan, Kelly Tatchell, David H. Hawke,Ryuji Kobayashi, and Sharon Y.R. Dent. The Set1 methyltransferase opposes Ipl1 Aurora kinase functions in chromosome segregation. (2005) Cell. 122: 1-12.
  10. Wenchu Lin, Chunhong Qiao, Qing Ye, Q and Guanglin Yin. (2002) Study on the Fermentation Condition of Producing 2-keto-L-gluconic acid by Using Mixed Culture of Microorganisms. MICROBIOLOGY 29(4): 27-41.
  11. Guanglin Yin, Wenchu Lin, Chunhong Qiao and Qing Ye. (2001) Production of Vitamin C Precursor--2-keto-L-gluconic Acids from D-sorbitol by Using Mixed Culture of Microorganisms. Acta. Microbiologica Sinica 41(6):709-715
  12. Wenchu Lin and Guanglin Yin. (2001) Study on the Genome size and Structure of Gluconobacter oxydans. SCB329. Acta. Microbiologica Sinica 41(5): 530-535.
  13. Wenchu Lin and Guanglin Yin. (2001) Determination of the Chromosome Length of Gluconobacter oxydans. SCB329. Acta. Microbiologica Sinica 41(1): 49-52.
  14. Zhengyi Xue, Wenchu Lin and Guanglin Yin. (2001) Study on the L-sorbose Dehydrogenase in Vitamin C Fermentation. Chinese Journal of Pharmaceuticals 32(3): 102-104.
  15. *Wenchu Lin, and Sharon YR Dent. (2006) Functions of histone modifying enzymes in development. Current Opinion in Genetics and Development. 16(2):137-42.
  16. *Wenchu Lin, (2000) Progress on the Pure Culture and Genome Research of Gluconobacter oxydans. SCB329. Industrial Microbiology 30(2): 18.

* reviews and book chapters