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Prof. WANG Wenchao

WANG Wenchao



Education Background



Molecular Cancer Biology



Biography & Introduction

WANG Wenchao graduated from Beijing Medical University (now Peking University) with a BS degree. He received his PhD degree in Molecular and Developmental Biology from Indiana University in 2008. He then did post-doctoral research in Dana-Farber Cancer Institute of USA from 2008 to 2012. After that, he joined the High Magnetic Field Laboratory of the Chinese Academy of Sciences in 2012 as an associate professor in 2012. Prof. WANG's main research areas include molecular biology, cancer biology, and biochemistry. He's had multiple publications in international SCI journals since 2002, including Cancer Cell, Immunology, Science, Development, and PLoS Genetics, etc.




Research Interests

Prof WANG's research mainly focuses on the development of kinase target-based whole cell screening library and functional assay systems regarding other non-kinase protein targets.


Selected Publications 

  1. Wang W, Zhong Q, Teng L, Bhatnagar N, Sharma B, Zhang X, Luther W, Haynes LP, Burgoyne RD, Vidal M, Volchenboum S, Hill DE, George RE. Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma. Oncogene. (accepted).
  2. Liu F, Zhang X, Weisberg E, Chen S, Hur W, Wu H, Zhao Z, Wang W, Mao M, Cai C, Simon NI, Sanda T, Wang J, Look AT, Griffin JD, Balk SP, Liu Q, Gray NS. Discovery of a Selective Irreversible BNX Inhibitor for Prostate Cancer. ACS Chem Biol. 2013 Apr 17. (in press)
  3. Zhang X, Bedigian AV, Wang W, Eggert US. G protein-coupled receptors participate in cytokinesis. Cytoskeleton (Hoboken). 2012 Oct;69(10):810-8.
  4. Zhang X, Wang W, Bedigian AV, Coughlin ML, Mitchison TJ, Eggert US. Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12485-90.
  5. Berry T, Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, Pei D, Sharma B, Vetharoy WR, Hallsworth A, Ahmad Z, Barker K, Moreau L, Webber H, Wang W, Liu Q,Perez-Atayde A, Rodig S, Cheung NK, Raynaud F, Hallberg B, Robinson SP, Gray NS, Pearson AD, Eccles SA, Chesler L, George RE. The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma. Cancer Cell. 2012 Jul 10;22(1):117-30.
  6. Zhu S, Lee JS, Guo F, Shin J, Perez-Atayde AR, Kutok JL, Rodig SJ, Neuberg DS, Helman D, Feng H, Stewart RA, Wang W, George RE, Kanki JP, Look AT. Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. Cancer Cell. 2012 Mar 20;21(3):362-73.
  7. Petrella LN*, Wang W*, Spike CA, Rechtsteiner A, Reinke V, Strome S. synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival. Development. 2011 Mar;138(6):1069-79.(* co-first authors)
  8. Rechtsteiner A, Ercan S, Takasaki T, Phippen TM, Egelhofer TA, Wang W, Kimura H, Lieb JD, Strome S. The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny. PLoS Genet. 2010 Sep 2;6(9).
  9. Fong Y, Bender L, Wang W, Strome S. Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans. Science. 2002 Jun 21;296(5576):2235-8.
  10. Zhang XY, Liu XG, Wang W, Wang WC, Gao XM. Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells. Immunology. 2003 Apr;108(4):465-73.