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Prof. TIAN Changlin
Time:2012-04-23

 

Detail

Name

TIAN Changlin 

Title

Professon/Vice Director 

Education Background

PhD 

Major

Molecular Biophysics 

Phone

+86-0551-5595125 

Email

cltian@hmfl.ac.cn

cltian@ustc.edu.cn 

Education:
09/1997 ~ 05/2003 Ph.D. in Molecular Biophysics, Institute of Biophysics,
Florida State University, Tallahassee, FL, USA
09/1995 ~ 07/1997 M.S. in Molecular Biology, Department of Biological Science
and Technology, Shanghai Jiao Tong University
09/1991 ~ 07/1995 B.S. in Applied Electronic Technology, Department of Information Control
B.S. in Biochemical Engineering, Department of Biological
Science and Technology
Shanghai Jiao Tong University, Shanghai, P. R. China

Working Experience and Affiliation:
08/2009 ~ Present Deputy Director of High Magnetic Field Laboratory, Chinese
Academy of Sciences, Hefei, Anhui, P. R. China
11/2006 ~ Present Professor of Biochemistry and Molecular Biology, School of
Life Science, University of Science and Technology of China,
Hefei, Anhui, P. R. China
03/2003 ~ 02/2007 Postdoctoral Research Associate, Center for Structural
Biology, School of Medicine, Vanderbilt University, Nashville,
Tennessee, USA
01/1998 ~ 03/2003 Research Assistant, Center for Interdisciplinary of Magnetic
Resonance, National High Magnetic Field Laboratory,
Tallahassee, FL, USA

Honor and Award:
09/2009 ~ Present Associate Director of Molecular Biophysics
Committee, Chinese Biophysics Society
09/2009 ~ Present Editor Board of Sinica Biophysics Acta.
04/2009 ~ Present General Secretary of Anhui Biochemistry and
Molecular Biology Association
12/2008 Young Faculty Career Award, University of Science and
Technology of China Alumni Foundation
12/2007 Young Investigator Award, Huo-Ying-Dong Education
Foundation
01/2006~ 12/2008 Postdoctoral Fellowship Award, American Heart
Association (stopped on 03/2006, due to resignation from Vanderbilt University)

Research Interests
Research interests in Dr. Changlin Tian’s lab is focusing on structure and
dynamic studies of membrane proteins, using combinational methods of
solution nuclear magnetic resonance (NMR), electronic paramagnetic
resonance (EPR), X-ray crystallography, and small angle X-ray scattering
(SAXS). Research topics including transporter and channel proteins in
Mycobacterium tuberculosis, mouse and human being; human G protein
coupled receptors, and other large size membrane associated proteins.
Some cutting edge biological technologies, such as unnatural amino acids
and their application in structural biology, automatic electrophysiology
analysis, receptor pharmacology studies were applied to aid structural and
dynamic studies of membrane proteins.

CURRENT RESEARCH PROJECTS
1) Structure, Dynamics and Physiology studies of Potassium Channel and its
Modulation Protein
2) Method Development of Magnetic Resonance (NMR, EPR) and combination
studies with other biophysical methods
REPRESENTATIVE PUBLICATIONS
1. Shi P, Wang H, Xi Z, Shi C, Xiong Y, Tian C, Site-Specific 19F NMR Chemical Shift
and Side Chain Relaxation Analysis of a Membrane Protein Labeled with an
Unnatural Amino Acid, Protein Science 20 (2010) 224-228
2. Xie X, Yang X, Chen L, Tian C, Long J, Shen Y Structural basis for tandem L27
domain-mediated polymerization FASEB J. 24 (2010) 4806-15
3. Vanoye CG, Welch RC, Tian C, Sanders CR, George AL Jr. KCNQ1/KCNE1
assembly, co-translation not required. Channels 2010 4(2):
4. Yan X, Zhou H, Zhang J, Shi C, Xie X, Wu Y, Tian C, Shen Y, Long J. Molecular
Mechanism of Inward Rectifier Potassium Channel 2.3 Regulation by Tax-
Interacting Protein-1 J. Mol. Bio. 2009 392(4):967-976
5. Van Horn WD, Kim HJ, Ellis CD, Hadziselimovic A, Sulistijo ES, Karra MD, Tian C,
Sönnichsen FD, Sanders CR Solution Nuclear Magnetic Resonance Structure of
Membrane Integral Diacylglycerol Kinase Science 2009 324(5935): 1726-1729
6. Kang, C*.,Tian, C*. Sonnichsen, F.D., Smith, J. A., Meiler, J., George, A.L., Vanoye,
C.G., Kim, H.J., Sanders, C.R. Preparation, Functional Characterization, and NMR
Studies of Human KCNE1, Structrue of KCNE1 and Implications for How it
Modulates the KCNQ1 Potassium Channel Biochemistry. 2008; 47:7999-8006 (*
Equal contribution)
7. Shi, C., Shao, W., Xiong, Y., Tian, C. A Gas Chromatography Method for
Quantification of Detergents frequently used in Membrane Protein Structural Studies
Anal. Biochem. 2008, 383: 326-328