Location: Home > About > Professors
Prof. ZHANG Xin





Professor /PI in Biology research

Education Background







Ph. D. in Biology
Indiana University, Bloomington. U.S. 2001-2007
Bachelor of Medicine   1996-2001
Peking University, Health Science Center
(previous name:Beijing Medical University), Beijing, China
Clinical Internship (Beijing Hospital) 1998-1999

Professional training and experience:
2008.3-2012.7 Research fellow in Ulrike Eggert lab in Dana Farber Cancer Institute, Cancer Biology Department and Harvard Medical School, Biological Chemistry and Molecular Pharmacology Department, Boston, MA
2007.4-2008.2 Postdoc in PhD thesis lab (Claire Walczak lab).
2001.9-2007.4 Ph.D Graduate student, Biology Department, Indiana University, Bloomington. Thesis advisor: Claire Walczak
2001-2002: Did three rotations in genetics, developmental biology and biochemistry lab.
2002. Worked on viral RNA synthesis in Dr. Cheng Kao’s lab
2002-2007. Worked on PhD thesis project: phospho-regulation of MCAK by Aurora kinases in Dr. Claire Walczak Lab.
2000-2001 Undergraduate research, Biochemistry Department, Beijing Medical University (current name: Peking University Health Science Center), Beijing, China.
1996-2001 Beijing Medical University (current name: Peking University Health Science Center).
10 months of clinical internship in Beijing hospital, Beijing, China.

2011-2012 Teaching Fellow
Optical Imaging in Modern Biomedical Research: Principles and Techniques, Harvard Extension School
2003-2004 Associate Instructor.
Medical microbiology lab, Indiana University.

Selected Publications:
1. Xin Zhang, Jing Liu, Wenchao Wang, Junfeng Wang, YundanJia, Qingsong Liu.Applications of fluorescent molecular probes in cell biology. Book chapter in “Fluorophores: Characterization, Synthesis and Applications” by Nova Science Publishers. ISBN: 978-1-62808-268-5.

2. Wenchao Wang, QuanZhong, Ling Teng, NamrataBhatnagar, Xin Zhang, William Luther, Lee P. Haynes, Robert D Burgoyne, Marc Vidal, Samuel Volchenhoum, David E Hill, Rani E George.2013.Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma. Oncogene. In Press. (IF:6.373)

3. Feiyang Liu#, Xin Zhang#, Ellen Weisberg#, Sen Chen#, WooyoungHur, Hong Wu, Zheng Zhao, Wenchao Wang, Mao Mao, ChangmengCai, Nicholas I. Simon, TakaomiSanda, Jinhua Wang, Thomas A. Look, James D. Griffin, Steve Balk, Qingsong Liu, Nathanael S. Gray. 2013. Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer. ACS Chemical Biology. Apr 17. [Epub ahead of print] PMID: 23594111. (IF:6.446) (#co-first authors).

4. Qingsong Liu, Chunxiaoxu, SivapriyaKirubakaran, Xin Zhang, WooyoungHur, Yan Liu, Nichlolas P. Kwiatkowski, Jinhua Wang, Kenneth Westover, PengGao, Dalian Erica, Carson C. Thoreen, Matthew P. Patricelli, Pasi A. Janne, Kwok Wong, David M. Sabatini, Nathanael S. Gray.2013. Biochemical, cellular and in vivo characterization of Torin2, an ATP-competitive mTOR, ATM and ATR inhibitor. Cancer Research. 73(8):2574-2586 (IF:7.856)

5. Ellen Weisberg, Qingsong Liu, Xin Zhang, Erik Nelson, Martin Sattler, Feiyang Liu, Maria Nicolais, Jianming Zhang, Constantine Mitsiades, Robert Smith, Richard Stone, Ilene Galinsky, Atsushi Nonami, James D. Griffin, and Nathanael Gray. 2013. Selective Akt Inhibitors Synergize with Tyrosine Kinase Inhibitors and Effectively Override Stroma-Associated Cytoprotection of Mutant FLT3-Positive AML Cells. PLoS ONE 8(2): e56473. DOI:10.1371/journal.pone.0056473(IF:4.092)

6. Xin Zhang, Wenchao Wang, Anne Bedigian, Margaret Coughlin, Tim Mitchison and Ulrike S. Eggert. 2012. Dopamine receptor DRD3 regulates endocytic sorting by a Prazosin-sensitive interaction with COPI. PNAS. 109(31):12485-90. (IF:9.681)

7. Xin Zhang, Anne Bedigian, Wenchao Wang and Ulrike S. Eggert. 2012. G-protein-coupled receptors Participate in cytokinesis. Cytoskeleton. 69(10):810-8 (IF~2.657)

8. Xin Zhang and Ulrike S. Eggert. 2012. Non-traditional roles of G-protein-coupled receptors in basic cell biology.MolBioSys. 9(4):586-95(IF:3.534)

9. Xin Zhang, Stephanie C. Ems-McClung and Claire Walczak. 2008. Aurora A Phosphorylates MCAK to Control Ran-dependent Spindle Bipolarity. Molecular Biology of the Cell. 19: 2752-2765.(IF:4.942)

10. Xin Zhang*. Aurora kinases. 2008. Current Biology. 18: R146-R148(IF:9.647)(*corresponding author)

11. Xin Zhang, WeijieLan, Stephanie C. Ems-McClung, Todd Stukenberg, Claire E. Walczak. 2007. Aurora B Phosphorylates Multiple Sites on Mitotic Centromere-associated Kinesin to spatially and temporally regulate Its Function. Molecular Biology of the Cell. 18:3264-3276. (IF:4.942)

12. Stephanie C. Ems-McClung,Kathleen M. Hertzer,Xin Zhang, Mill Miller, and Claire E. Walczak. The N- and C-terminal domains of MCAK regulate microtubule depolymerization activity and spindle assembly. 2007. Molecular Biology of the Cell. 18: 282-294. (IF:4.942)

13. Xin Zhang and Claire E. Walczak. 2006. Chromosome Segregation: Correcting Improperly Attached Chromosomes. Current Biology. 16: r677-679. (IF:9.647)

14. Per Holmfeldt,Xin Zhang, Sonja Stenmark, Claire E Walczak and Martin Gullberg. 2005. CaMKII -mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation. EMBO J. 24: 1256-1266.(IF:9.205)

15. WeijieLan#, Xin Zhang#, Susan L. Kline-Smith, Sara E. Rosasco, Gregory A. Barrett-Wilt, Jeffrey Shabanowitz, Donald F. Hunt, Claire E. Walczak, P. Todd Stukenberg. 2004. Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity. Current Biology. 14:273-286. (# co-first authors).(IF:9.647)

16. Xin Zhang,Chul-Hyun Kim, K. Sivakumaran, Cheng Kao. 2003. Stable RNA structures can repress RNA synthesis in vitro by the brome mosaic virus replicase. RNA. 9: 555-565.(IF:5.095)

17. C. T. Ranjith-Kumar, Xin Zhang, Cheng Kao. 2003. Enhencer-like activity of a brome mosaic virus RNA promoter. Journal of Virology. 77: 1830-1839.(IF:5.402) 

Main Research Interest:
1. Cellular responses and molecular mechanisms in high static magnetic field.
2. Small molecular inhibitors of membrane trafficking and/or cell division.
3. Endocytosis, membrane trafficking and cell division.