ZHAO Guoping
Professor of Biophysics
Associate director of life science division

Education and Research Experience

2015-now Professor, Hefei Institutes of Physical Science, CAS, China
2011-2015 Postdoctor, Brown Cancer Center, University of Louisville, USA
2005-2010 Ph.D., Hefei Institutes of Physical Science, CAS, China
2001-2005 B.Sc., Anhui University, China

Research Interest

  1. Key targets and regulatory mechanisms of tumor radiotherapy. These include the mining of key regulatory genes and pathways of different radiation particles, the clarification of regulatory mechanisms of key targets to radiation, and the screening of multi-target radiotherapy sensitization drugs.
  2. The role of different subcellular organelles in the process of DNA repair or apoptosis.
    Using NMR spectroscopy to screen radiosensitizers.

Recent Publications (*correspondence)

  1. Chen B, Xu F, Gao Y, Hu G, Zhu K, Lu H, Xu A, Chen S, Wu L, Zhao G*. DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity. Oncogene. 2022 Mar,41(13):1918-1930.
  2. Zhao G*. Editorial: The Role of Different Subcellular Organelles in DNA Damage Response. Front Cell Dev Biol. 2021 Oct 28,9:760023.
  3. Wang X, Nie Y, Si B, Wang T, Hei TK, Du H, Zhao G, Chen S, Xu A*, Liu Y*. Silver nanoparticles protect against arsenic induced genotoxicity via attenuating arsenic bioaccumulation and elevating antioxidation in mammalian cells. J Hazard Mater. 2021 Jul 5;413:125287.
  4. Liu Y, Wang T, Si B, Du H, Liu Y, Waqas A, Huang S, Zhao G, Chen S, Xu A*. Intratracheally instillated diesel PM2.5 significantly altered the structure and composition of indigenous murine gut microbiota. Ecotoxicol Environ Saf. 2021 Mar 1;210:111903.
  5. Gao Y, Wen P, Chen B, Hu G, Wu L, Xu A, Zhao G* Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells. International Journal of Molecular Sciences. 2020 Sep 12,21(18):6692.
  6. Chen B, Wen P, Hu G, Gao Y, Qi X, Zhu K, Chen Sg, Wu L, Xu An, Zhao G* Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation through Potentiating the Transcription of e2f1 Target Gene apaf1, Frontiers in Cell and Developmental Biology, 2020 Jun 12,8:408. doi: 10.3389.
  7. Wen P, Gao Y, Chen B, Qi X, Hu G, Xu A, Xia J, Wu L, Lu H*, and Zhao G* Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers, Cancers (Basel), 2020 Apr 13,12(4):957.
  8. Cao X, Wen P, Fu Y, Gao Y, Qi X, Chen B, Tao Y, Wu L, Xu A, Lu H*, Zhao G*. Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells. Cell Signalling. 2019 Jun 4. 62:109337.
  9. Wang J, Nie Y, Dai H, Wang M, Cheng L, Yang Z, Chen S, Zhao G, Wu L, Guang S, Xu A*, Parental exposure to TiO2 NPs promotes the multigenerational reproductive toxicity of Cd in Caenorhabditis elegans via bioaccumulation of Cd in germ cells, Environmental Science-Nano, 2019, 6(5): 1332-1342.
  10. Wang M, Wang J, Liu Y, Wang J, Nie Y, Si B, Liu Y, Wang X, Chen S, Hei TK, Wu L, Zhao G*, Xu A*. Subcellular targets of zinc oxide nanoparticles during the aging process: role of cross-talk between mitochondrial dysfunction and endoplasmic reticulum stress in the genotoxic response. Toxicol Sci. 2019 Jun 7.
  11. Sun Y, Dai H, Chen S*, Zhang Y, Wu T, Cao X, Zhao G, Xu, An, Wang J, Wu L*, Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy, Molecular Therapy, 2018, 26(10): 2456-2465.
  12. Chen B, Cao X, Lu H, Wen P, Qi X, Chen S, Wu L, Li C, Xu A*, Zhao G*. N-(3-oxo-acyl) homoserine lactone induced germ cell apoptosis and suppressed the over-activated RAS/MAPK tumorigenesis via mitochondrial-dependent ROS in C. elegans. Apoptosis. 2018 Dec,23(11-12):626-640.
  13. Wen P, Xia J, Cao X, Chen B, Tao Y, Wu L, Xu A, Zhao G*. dbCRSR: a manually curated database for regulation of cancer radiosensitivity. Database (Oxford). 2018 Jan 1, doi: 10.1093/database/bay049.
  14. Liu Y, Nie Y, Wang J, Wang J, Wang X, Chen S, Zhao G, Wu L, Xu A*, Mechanisms involved in the impact of engineered nanomaterials on the joint toxicity with environmental pollutants, Ecotoxicology and Environmental Safety, 2018, 162: 92-102.
  15. Wang X, Zhao G, Wang H, Liang J, Xu S, Chen S, Xu A*, Wu, Lijun*, Assessment of the cytotoxic and mutagenic potential of the Jialu River and adjacent groundwater using human-hamster hybrid cells, Journal of Environmental Sciences, 2018, 70:133-143.
    Dai H, Liu Yn, Wang J, Nie Y, Sun Y, Wang M, Wang D, Yang Z, Cheng L, Wang J, Weng J, Wang Q, Wang F, Wu L, Zhao G, Xu A*, Graphene oxide antagonizes the toxic response to arsenic via activation of protective autophagy and suppression of the arsenic-binding protein LEC-1 in Caenorhabditis elegans, Environmental Science-Nano, 2018, 5(7): 1711-1728.
  16. Neely AM, Zhao G, Schwarzer C, Stivers N, Whitt A, Meng S, Burlison J, Machen T, Li C*, N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts, Cellular Microbiology, 2018, 20(1): 1-15


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