Life Science
Visit the website of Dr. LIN Wenchu's Laboratory
Education
Ph.D. (2006), Biomedical Sciences, Univ. of Texas M D Anderson Cancer Center & Univ. of Texas Health Science Center at Houston, Houston, USA
Ms.C. (2001), Biochemistry and Molecular Biology, Shanghai Institutes for Biological Sciences, CAS, Shanghai, China
B.Sc. (1996), Microbiology, Sichuan Univ., Chengdu, Sichuan, China
Research Interests
1. Cancer epigenetics
2. Molecular vulnerabilities in small cell lung cancer
3. Targeted cancer therapies
Selected Publications
1) Jinghan Hua#, Xiaolin Wang#, Liying Ma, Jingxin Li, Guozhen Cao, Shaobo Zhang, Wenchu Lin*. CircVAPA promotes small cell lung cancer progression by modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis. Molecular Cancer. 2022. Accepted.
2) Yang Lv#, Xiaotong Lv#, Jiahui Zhang, Guozhen Cao, Changzhi Xu, Buchang Zhang, Wenchu Lin*. BRD4 targets the KEAP1-Nrf2-G6PD axis and suppresses redox metabolism in small cell lung cancer. Antioxidants. 2022 Mar 29;11(4):661. doi: 10.3390/antiox11040661.
3) Xiaolin Wang#, Jingxin Li#, Xing Bian, Cheng Wu, Jinghan Hua, Shuhui Chang, Tianyi Yu, Hong Li, Yongxiang Li, Shanshan Hu*, Ge Shan*, Wenchu Lin*. CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer. Proceedings of the National Academy of Sciences of the United States of America. 2021. August 17; 118 (33) e2012881118;
4) Yanping Yin#, Wenhao Shi#, Ke Deng, Xiaoli Liu, Hong Li, Xiaotong Lv, Vivian Wai Yan Lui, Chen Ding*, Bo Hong*, Wenchu Lin*. Combinations of proteasome inhibitors with obatoclax are effective for small cell lung cancer. Acta Pharmacologica Sinica. 2021 Aug;42(8):1298-1310.
5) Liying Ma#, Xing Bian#, Wenchu Lin*. The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer. Journal of Experimental & Clinical Cancer Research. 2020 Oct 17;39(1):219.
6) Hongji Liu#, Xiaotong Lv#, Junchao Qian#, Hong Li, Yong Qian, Xingyu Wang, Xiangfu Meng, Wenchu Lin*, Hui Wang*. Graphitic carbon nitride quantum dots embedded in carbon nanosheets for near-infrared imaging-guided combined photo-chemotherapy. ACS Nano. 2020 Oct 27;14(10):13304-13315.
7) Ao Xu#, Wei Wang#, Bo Hong*, Wenchu Lin*. Germline mutation and aberrant transcripts of WWOX gene in syndrome with multiple primary tumors. Journal of Pathology. 2019 Sep; 249(1):19-25.
