Prof. Zhang Na's group----High Magnetic Field Laboratory, Chinese Academy of Sciences

Professors

research_groups

Prof. Zhang Na's group

Research Interest

Currently in Na Zhang's lab, nucleic acid structural biology is the main scheme. In particular, the solution NMR (Nuclear Magnetic Resonance) spectroscopy will be used as a primary tool to understand the structure, dynamics, function and mechanism of biologically significant RNA and DNA, as well as their corresponding complexes interacted with protein or small molecule ligand.

Tri-GQ structure

Research

#1: Thioflavin T preferentially binds with RLP-form over coexisting LLP-form of pseudo-mirror hetero-GQs

#2: Fast strand exchanges between the folded tri-GQ and the unfolded single-strand species of d(GTTAGG)

Members

Principal Investigator：Na ZHANG

Associate professors：

Tao Wang

Postdoctors

Haitao Jing

Wenqiang Fu

Graduate students:

Wenxuan Hu

Di Gao

Fengnan LiuXinmeng Bi

Zhiyue Liu

Huiying Yuan

Cece Wang

Former students:

Huihui Li, Miao He, Ting Zhu, Xiaojuan Xu

Publications

Fu WQ, Jing HT, Zhang N. Two coexisting pseudo-mirror heteromolecular telomeric G-quadruplexes in opposite loop progressions differentially recognized by a low equivalent of Thioflavin T. Nucleic Acids Res. (2021) 49(18), p10717-10734.
Jing HT, Fu WQ, Zhang N. NMR structural study on the self-trimerization of d(GTTAGG) into a dynamic trimolecular G-quadruplex assembly preferentially in Na+ solution with a moderate K+ tolerance. Nucleic Acids Res. (2021) 49(4), p2306-2316.
Wan CJ, Fu WQ, Jing HT, Zhang N. NMR solution structure of an asymmetric intermolecular leaped V-shape G-quadruplex: selective recognition of the d(G2NG3NG4) sequence motif by a short linear G-rich DNA probe. Nucleic Acids Res. (2018) 47(3), p1544-1556
Zhang N, Phan A, Patel D. (3+1) assembly of three human telomeric DNA repeats into an asymmetrical dimeric G-quadruplex. J Am Chem Soc. (2005) 127, p17277-17285.
Zhang N, Zhang SL, Szostak JW. Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template. J Am Chem Soc. (2012) 134, p3691-3694.
Zhang S, Zhang N, Blain JC, Szostak JW. Synthesis of N3′-P5′-linked Phosphoramidate DNA by Nonenzymatic Template-Directed Primer Extension. J Am Chem Soc. (2013), 135, p924-932.
Trevino S, Zhang N, Elenko M, Lupt k A, Szostak JW. Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity. Proc Natl Acad Sci USA (2011) 108, p13492-13497.
Zhang N, Ding S, Kolbanovskiy A, Shastry A, Kuzmin VA, Bolton JL, Patel DJ, Broyde S, Geacintov NE. NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms. Biochemistry (2009) 48, p7098-7109.
Zhang N, Lin Y, Xiao Z, Jones GB, Goldberg IH. Solution structure of a designed spirocyclic helical ligand binding at a two-base bulge site in DNA. Biochemistry (2007) 46, p4793-4803.

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