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Discovery of a selective irreversible BMX inhibitor for prostate cancer

Jul 11,2013|By Liu F, Zhang X, Weisberg E, Chen S, Hur W, Wu H, Zhao Z, Wang W, Mao M, Cai C, Simon NI, Sanda T, Wang J, Look AT, Griffin JD, Balk SP, Liu Q, Gray NS ACS Chem Biol. 2013 Apr 17

BMX is a major member of the TEC family of non-receptor tyrosine kinases expressed in the prostate epithelium. Due to the activation of BMX in response to phosphoinositide 3-kinase (PI3K)/Akt signaling, which is increased in prostate cancer, Liu et al. were interested in the potential anti-proliferative effects of BMX inhibition....

Ralative Link: http://f1000.com/prime/718001438

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