Discovery of N-(3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective,Potent, and Orally Available Type II c-KIT Kinase Inhibitor for GISTs

Mar 21,2017|By Qiang Wang,？Feiyang Liu,？Beilei Wang,？Fengming Zou,？Cheng Chen,？Xiaochuan Liu,？Aoli Wang,？Shuang Qi,？Wenchao Wang,？Ziping Qi,？Zheng Zhao,？Zhenquan Hu,？Wei Wang,？Li Wang,？Shanchun Zhang,？Yuexiang Wang,？Jing Liu, and？Qingsong Liu. DOI:？10.1021/acs.jmedchem.6b00200