Professors

Life Science

Life Science

WANG Junfeng
Professor of Biomolecular NMR Research

 

Visit the website of Dr. WANG Junfeng's laboratory 

 

Biography & Introduction

WANG Junfeng, Vice President of HFIPS of the Hefei Institutes of Physical Science(HFIPS). He received his PhD degree from National High Magnetic Field Laboratory/Florida State University in 2001. Before joining High Magnetic Field Laboratory of CAS, he conducted postdoctoral researches at University of Georgia and Harvard Medical School. 
   

Education Background

2001    Ph.D.    National High Magnetic Field Laboratory/Florida State University 

1995    M.S.     Beijing Medical University  

1992    B.S.      Department of Chemistry, Peking University

Professional Activities 

2009- present    Joint professor, University of Science and Technology of China (USTC)  

2009- present    Professor and director, Magnetic Resonance Division, CHMFL                  

2004-2009         Postdoctoral researcher, Department of Biological Chemistry and Molecular Pharmacology,

                           Harvard Medical School

2001-2004         Postdoctoral researcher, Southeast Structural Genomics Center, University of Georgia 

 

Research

Research Interests
Many important biological functions, such as the cross-membrane nutrients transport, neural signal transduction, cell-cell interactions are implemented by membrane proteins, which count for 30% of the protein genomes. Mutations and dysfunctions of membrane proteins and membrane-associated proteins result in various diseases, and over 60% of current drug targets are membrane proteins. The ongoing researches in the lab focus on membrane protein structure determination and protein-lipid interactions, with the goal of providing structural and dynamical insights on cross-membrane signaling and other protein-membrane recognition events. The primary tool we are using is solution NMR spectroscopy, which is ideal for determining protein structure, characterizing protein dynamics and inter-molecular interactions in solution. 

Recent Publications 

  1. Hua Li, Lei Zhu, Shulin Hou, Jing Yang, Junfeng Wang, Jinsong Liu*, (2014) An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease.  FEBS Letters, (In press,http://dx.doi.org/10.1016/j.febslet.2014.05.063) (*co-corresponding authors)
  2. Shi X#, Bi Y#, Yang W#, Guo X, Jiang Y, Wan C, Li L, Bai Y, Guo J, Wang Y, Chen X, Wu B, Sun H, Liu W, Wang J*, Xu C*. (2013) Ca2+ regulates T cell receptor activation by modulating phospholipid electrostatic property. Nature 493(7430):111-5. (#Co-first authors, *co-corresponding authors)
  3. Jing Liu, Feiyang Liu, David L. Waller, WANG Junfeng and Qingsong Liu,(2012)Kinase Inhibitors Targeting Anti-angiogenesis as Anti-cancer Therapies,Current Angiogenesis,335-346 (12).
  4. Y. Bi, L. Zhu, H. Li, B. Wu, J. Liu*, J. Wang *, (2012) "Backbone 1H, 13C and 15N resonance assignments of Dengue Virus NS2B-NS3p in complex with aprotinin". Biomolecular NMR Assign(In press,doi: 10.1007/s12104-012-9395-9).
  5. J. Liu, Y. Hu, D. L. Waller, J. Wang and Q. Liu, (2012) "Natural Products as Kinase Inhibitors", Natural Product Reports, 29(3):392-403.
  6. Z. Huang#, C. Ye#, Z. Liu#, X. Wang, H. Chen, Y. Liu, L. Tang, H. Zhao, J. Wang, W. Feng, and X. Li, (2012), "Solid-Phase N-Terminus PEGylation of Recombinant Human Fibroblast Growth Factor 2 on Heparin-Sepharose Column", Bioconjugate Chem,23 (4), pp 740–750. (#: Co-first authors)
  7. X. Zhang, G. Meng, Q. Huang, J. Wang, M. Wang, M. Li and C. Tang, (2011) "A potential fluorescence detection approach to trace hexachlorobenzene via disaggregating with ethanol",Analyst,136:4912-4915.
  8. Y. Hu, J. Liu, J. Wang and Q. Liu, (2011)"The controversial links among calorie restriction, SIRT1, and resveratrol", Free Radical Biology and Medicine,51(2)：250-256.
  9. Y. Bi, Y. Wang and J. Wang, (2011) "The Nanodiscs: A Novel Tool to Study Membrane Protein Structure and Function", Chinese Journal of Magnetic Resonance, 28(2):177-189.
  10. J. Wang, R. Pielak, M. McClintock and J. Chou, (2009)"Solution Structure and Functional Analysis of the Influenza B Proton Channel", (featured story) Nature Struct. Mol. Biol. 16(12):1267-1272.
  11. H. Shen, J. Wang, L. Yao, J. Yang and K. Chou, (2009) "Recent Progress of Bioinformatics in Membrane Protein Structual Studies", Automation in Genomics and Proteomics: An Engineering Case-Based Approach, Wiley Publishing, P. 293-308.

 

Publications Before 2009 

  1. J. Wang and H. Valafar, J. Prestegard, (2005) "Assessment of Protein Alignment Using 1H-1H Residual Dipolar Couplings Measurements", J.  Magn. Reson. 172(1):85-90.
  2. J. Wang, J. R.,Schnell, and J. Chou, (2004) "Amantadine Partition and Localization in Phospholipid Membrane: A solution NMR Study". BioChem. Biophys. Res. Comm. 324 (1): 212-217.
  3.  S. L. Grage, J. Wang, T. A. Cross and S. Ulrich, (2002) "Solid-state 19F NMR Analysis of 19F-Labeled Tryptophan in Gramicidin A in Oriented Membranes", Biophysics. J. 83:3336-3350.
  4. J. Wang, S. Kim, F. Kovacs, and T.A. Cross, (2001) "M2 Protein H+ Channel: A Refined Backbone Structure for the Transmembrane Region", Protein Sci. 10 (11):2241-2250 (cover story) .
  5. J. Denny, J. Wang, J. R. Quine, and T. A. Cross, (2001) "PISEMA Powder Patterns and PISA wheels" J.  Magn. Reson. 152 (2): 217-226.
  6. T. A. Cross, S. Kim, Z. J. Wang, and J. R. Quine, (2001) "From Topology to High Resolution Membrane Protein Structures", proceedings of the Workshop on the Future of Solid STATE NMR in Biology, Leiden, Then Netherlands. P.55-70.
  7. Z. Song, F. A. Kovacs, J. Wang, J. Denny, S. C. Shekar, J. R. Quine, and T. A. Cross, (2000) "Transmembrane Domain of M2 Protein from Influenza A Virion as studied by PISEMA in Solid-state 15N NMR," Biophysics. J. 79:767-775.
  8. J. Wang, J. Denny, C. Tian, S. Kim, Y. Mo, F. Kovacs, Z. Song, Z. Gan, R. Fu, J. R. Quine, and T. A. Cross, (2000) "Imaging membrane protein helical wheels", J.  Magn. Reson. 144:162-167(cover story).
  9. T. A. Cross, F. Tian, M. Cotten, J. Wang, F. Kovacs, and R. Fu, (1999) " Correlations of Structure, Dynamics and Function in the Gramicidin Channel by Solid State NMR", Proceedings of the Novartis Foundation Symposium No. 225: Gramicidin and Related Ion Channel-Forming Peptides, John Wiley & Sons, LTD, P.4-22.
  10. G. Zhou#, J. Wang#, E. Blanc and M. S. Chapman, (1998) "Determination of the Relative Precision of Atoms in a Macromolecular Structure", Acta Crystallographica D53:391-399. (#: Co-first authors)

 

 

 

   
 
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